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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Pilocytic astrocytoma and glioneuronal tumor with histone H3 K27M mutation

Fig. 2

The pathologic and radiologic imaging of Patient 2; a axial T1-weighted contrast-enhanced MRI immediately preoperative; b axial T1-weighted contrast-enhanced MRI 22 months postoperative showing no residual tumor; c axial T2 FLAIR MRI immediately preoperative; d axial T2 FLAIR MRI 22 months postoperative showing no residual/recurrent tumor; histological evaluation shows a predominantly small round blue cell tumor tumor (e) with neuropil islands and rosettes (f); the tumor was strongly positive for neuronal differentiation marker synaptophysin (g). While small round blue cells were negative for GFAP, rare scattered larger GFAP positive cells were noted (g, insert). Tumor was strongly positive for histone H3 K27M (h); i copy number analysis using Illumina 450 k Infinium array showed no large chromosomal gains or losses of focal amplifications in glioma associated genes (blue labels)

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