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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy

Fig. 4

a-d The microglial response was assessed by staining for Iba1. Compression induced a significant accumulation of Iba1+ cells above, below, and at the site of cord compression (**p < 0.01, ***p < 0.001, ****p < 0.0001). Following decompression, Iba + microglia reduced above and at the site of compression (**p < 0.01). e-h) Interestingly, compression resulted in a marked loss of GFAP-positive astrocytes at the level of the lesion (**p < 0.01). Conversely, a marked astrocytosis was detected above and below the site of compression (**p < 0.01, ***p < 0.001). The absence of astrocytes at the area of compression and the reactive astrocytosis above and below persisted following decompression. i-l Visualization of myelin with fluorescent dies (Fluoromyelin) failed to demonstrate frank demyelination. Scale bar: b-d = 0 μm; f-h, j-l = 100 μm

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