Structure and functional domains of FUS. FUS is a member of the TET family of proteins, and contains several functional domains including a QGSY-rich region, multiple RNA binding regions, a C-terminal Zinc-finger motif and two putative ‘prion-like’ domains. The majority of mutations in ALS-FUS are located within the C-terminal nuclear localization signal domain in exon 15. Figure adapted by author from Vance et al.  and Deng et al.