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Table 1 Comparison of microarray and QPCR measurements on homogenates of cortical gray matter derived from the Control versus Edema and Control versus Pressure groups of patients

From: Human neuronal changes in brain edema and increased intracranial pressure

Gene symbol Microarray QPCR
Log2 change ([odema] vs [cont]) p value (OneWay Welch ANOVA) Fold change Regulation Log2 change (ΔΔCt [odema] vs [cont]) p value (Student’s ttest) Fold change Regulation
  Control versus Edema
AQP1 1.71 0.0383 3.26 up 5.20 0.0000 36.85 up
AQP3 2.28 0.0007 4.87 up 3.02 0.0005 8.11 up
CACNA1B −1.06 0.0282 −2.09 down −2.71 0.0025 −6.55 down
CRH −2.82 0.0000 −7.06 down −3.59 0.0046 −12.00 down
DRD5 −1.17 0.0037 −2.26 down −3.32 0.0045 −9.98 down
GABRA4 −2.12 0.0091 −4.36 down 1.02 0.1008 2.03 up
GNRH1 −0.35 0.0629 −1.28 nc −2.14 0.0309 −4.42 down
GRIA3 −1.34 0.0132 −2.53 down −2.59 0.0058 −6.03 down
GRID1 −1.12 0.0230 −2.17 down 0.42 0.6465 1.34 nc
HMOX1 1.68 0.0013 3.21 up 2.57 0.0035 5.93 up
KCNN4 1.58 0.0002 2.99 up 1.63 0.0434 3.09 up
KCTD12 1.06 0.0025 2.09 up 0.34 0.6573 1.27 nc
NEUROD6 −2.37 0.0020 −5.17 down −0.16 0.8805 0.89 nc
NPY1R −1.61 0.0122 −3.06 down −1.55 0.0069 −2.93 down
SCN3B 1.33 0.0235 2.52 up 2.07 0.0057 4.20 up
SOD2 1.01 0.0030 2.02 up 3.33 0.0014 10.06 up
  Control versus Pressure
AQP1 0.13 0.0383 1.09 nc 4.78 0.0015 27.38 up
GRIK4 0.18 0.0237 1.13 nc −2.44 0.0144 −5.41 down
HTR5A 1.20 0.0178 2.29 up 1.44 0.0221 2.71 up
KCNAB3 0.90 0.0008 1.86 up 1.52 0.0279 2.87 up
KCNS1 1.09 0.0200 2.14 up 3.05 0.0006 8.25 up
KCNS3 1.09 0.0024 2.13 up 0.77 0.5766 1.71 nc
PVALB 1.16 0.0011 2.24 up 2.02 0.0056 4.04 up
SLC2A3 −0.37 0.0231 −1.30 nc −1.21 0.0267 −2.31 down
SLC2A9 −0.22 0.4318 −1.16 nc −2.01 0.0056 −4.02 down