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Table 1 The numbers of perivascular cuffs (total numbers/numbers with AQP4 loss) in retinal nerve fiber layer (RNFL), inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear layer (ONL), as determined from one retinal section/rat

From: Aquaporin 4-specific T cells and NMO-IgG cause primary retinal damage in experimental NMO/SD

Treatment

# rats

# of perivascular cuffs in RNFL (total/AQP4 loss)

# of perivascular cuffs in INL/OPL/ONL (total/with AQP4 loss)

T + NMO-IgGS

5

5/0

3/1

T + NMO-IgGV

4

8/0

12/8

T + NMO-IgG9

2

6/0

n.d.

T + co-IgG

4

17/0

8/0

  1. Please note that not every inflammatory lesion in the INL/OPL/ONL region was associated with AQP4 loss. This was also observed in spinal cord sections of Lewis rats with experimental NMO [9, 11]