Fig. 1
From: Aquaporin 4-specific T cells and NMO-IgG cause primary retinal damage in experimental NMO/SD
Inflammation and astrocyte-destructive lesions in the anterior visual pathway. Shown here is a scheme of the anterior visual pathway in rats (a) and schemes of cross sections through the brain at different levels along the neuraxis to show important areas of the anterior visual pathway (b,g,l,p) which were then analyzed in ENMO rats following staining with anti-CD3 antibodies (brown) to visualize T cell infiltrates (c,h,m,q), and with anti-AQP4 antibodies (brown) to visualize loss of AQP4 reactivity (d,i,n,r). *: lesions with AQP4 loss outside the anterior visual pathway. Black boxes: selected regions shown after staining with anti-GFAP antibodies (brown, e,f,j,k,o,s). Hematoxylin staining was used to reveal nuclei (blue). For all drawings, schemes provided by Paxinos and Watson [38] and by Mueller [39] served as guide lines. Bars = 500 μm (c,d,h,i,m,n), 300 μm (q,r,s), and 100 μm (e,f,j,k,o)