Table 3 Univariate and multivariate Cox analysis of genetic and clinical determinants of paediatric thalamic glioma

Histology (HG vs. LG)

9.905 [4.378–22.408]

<0.0001

7.721 [2.437–24.461]

<0.0001

Surgery (resection vs. biopsy)

0.399 [0.191–0.831]

0.014

0.325 [0.122–0.869]

0.025

Chemo. (yes vs. no)

0.969 [0.441–2.127]

0.969

0.549 [0.213–1.416]

0.215

Rad. (yes vs. no)

1.048 [0.459–2.396]

0.911

0.898 [0.343–2.349]

0.827

H3K27M (mut. vs. WT)

9.403 [4.253–20.788]

<0.0001

6.945 [2.190–22.020]

<0.0001

MAPK Activation (mut. vs. WT)

0.190 [0.072–0.500]

0.001

0.385 [0.134–1.102]

0.075