| Univariate | Multivariate | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OS | PFS | OS | PFS | ||||||||||
HR | 95Â % C.I. | p-value | HR | 95Â % C.I. | p-value | HR | 95Â % C.I. | p-value | HR | 95Â % C.I. | p-value | ||
Cohort | Cohort 1 | 0.81 | 0.643–1.030 | 0.09 | 1.11 | 0.884–1.398 | 0.37 | excluded by factor selection with step-wise method | excluded by factor selection with step-wise method | ||||
Cohort 2 | Ref | Ref | |||||||||||
Location | Cerebrum | 0.91 | 0.504–1.624 | 0.74 | 0.81 | 0.489–1.357 | 0.43 | excluded by factor selection with step-wise method | excluded by factor selection with step-wise method | ||||
Cerebrum with Frontal Involvement | 0.93 | 0.511–1.705 | 0.82 | 0.78 | 0.458–1.317 | 0.35 | |||||||
 | Other | Ref | Ref | ||||||||||
Age |  | 1.015a | 1.004–1.025 | 0.006 | 1.004a | 0.995–1.013 | 0.38 | 1.01a | 1.004–1.025 | 0.008 | excluded by factor selection with step-wise method | ||
Sex | M | Ref | Ref | excluded by factor selection with step-wise method | excluded by factor selection with step-wise method | ||||||||
 | F | 0.72 | 0.570–0.918 | 0.008 | 0.78 | 0.621–0.975 | 0.03 | ||||||
KPS |  | 0.992b | 0.985–0.999 | 0.03 | 0.999b | 0.992–1.006 | 0.74 | 0.99b | 0.982–0.997 | 0.009 | excluded by factor selection with step-wise method | ||
Surgery | Biopsy | 2.59 | 1.725–3.899 | <0.0001 | 2.06 | 1.349–3.130 | 0.0008 | 3.15 | 2.082–4.769 | <0.0001 | 2.22 | 1.454–3.380 | 0.0002 |
 | Removal | Ref | Ref | Ref | Ref | ||||||||
TERT | wild-type | 0.73 | 0.568–0.925 | 0.01 | 0.73 | 0.581–0.922 | 0.008 | Interacts with MGMT | <0.0001 | 0.65 | 0.513–0.821 | 0.0003 | |
 | mutated | Ref | Ref |  | Ref | ||||||||
MGMT | Methylated | 0.43 | 0.325–0.561 | <0.0001 | 0.51 | 0.396–0.656 | <0.0001 | Interacts with TERT | <0.0001 | 0.48 | 0.368–0.613 | <0.0001 | |
 | Unmethylated | Ref | Ref |  | Ref | ||||||||
TERT-MGMT | TERT-MGMT interaction | Â | Â | 0.006 | excluded by factor selection with step-wise method | ||||||||
 | Wt/Met | 0.32 |  |  | |||||||||
 | Mut/Met | 0.27 |  |  | |||||||||
 | Wt/Un-met | 0.54 |  |  | |||||||||
 | Mut/Un-met | Ref |  |  |