Fig. 4

Kaplan-Meier analysis for survival, stratified by TERT and MGMT statuses in 453 GBM cases treated with radiation plus temozolomide. a. PFS of GBM cases (see text for definition). Median PFS was 14.5 months for TERT mutated-MGMT methylated (Mut/Met), 12.8 months for TERT wild-type-MGMT methylated (WT/Met), 9.8 months for TERT wild-type-MGMT unmethylated (WT/Un-met), and 7.2 months for TERT mutated-MGMT unmethylated (Mut/Un-met) (P < 0.0001, Log-rank test). The Mut/Un-met group showed shorter PFS than WT/Un-met (P = 0.0003, Log-rank test), whereas the differences in PFS between the MGMT methylated groups (between Mut/Met and WT/Met) was not significant (P = 0.62, Log-rank test). b. OS of the GBM cases. Median OS was 30.0 months for Mut/Met, 26.5 months for WT/Met, 18.8 months for WT/Un-met, and 14.6 months for Mut/Un-met (P < 0.0001, Log-rank test). The Mut/Un-met group had shorter OS than WT/Un-met (P < 0.0001, Log-rank test), whereas the difference in OS between Mut/Met and WT/Met was not significant (P = 0.83, Log-rank test). GBM, glioblastoma; OS, overall survival; PFS, progression free survival