Table 3 Survival analyses of clinical and biological markers in the recent and the entire cohort
Parameters | Overall survival | Progression free survival | Overall survival | |||
|---|---|---|---|---|---|---|
1992–2014 | 1992–2014 | 1965–2014 | ||||
(n = 27) | (n = 27) | (n = 46) | ||||
HR (95Â % CI) | p-value | HR (95Â % CI) | p-value | HR (95Â % CI) | p-value | |
Univariate | Â | Â | Â | Â | Â | Â |
Age (years) | 0.957 (0.807; 1.135) | 0.609 | 0.930 (0.800; 1.080) | 0.324 | 0.956 (0.875; 1.046) | 0.322 |
Extent of resection GTR/non-GTR | 1.416 (0.173; 11.57) | 0.744 | 5.379 (1.068; 27.08) | 0.042 | 2.876 (1.243; 6.657) | 0.010 |
WHO grade II/III | 7.289 (0.911; 942.8) | 0.065 | 2.421 (0.516; 11.36) | 0.249 | 1.094 (0.448; 2.670) | 0.844 |
TNC positive/negative | 3.739 (0.470; 483.4) | 0.184 | 6.624 (0.841; 856.9) | 0.079 | 9.583 (1.323; 1219) | 0.031 |
LAMA2 positive/negative | 1.800 (0.369; 8.776) | 0.461 | 1.701 (0.466; 6.209) | 0.416 | 1.141 (0.497; 2.619) | 0.756 |
Chromosome 1q25 gain/no gain | 4.374 (1.085; 17.63) | 0.024 | 4.855 (1.342; 17.56) | 0.008 | 2.474 (0.915; 6.692) | 0.065 |
Multivariable (n = 26/26/38) |  |  |  |  |  |  |
TNC positive/negative | 1.872 (0.067; 52.31) | 0.712 | 4.593 (0.505; 608.6) | 0.348 | 3.807 (0.453; 496.7) | 0.391 |
Chromosome 1q25 gain/no gain | 4.409 (0.894; 21.74) | 0.068 | 5.204 (1.369; 21.76) | 0.024 | 2.025 (0.745; 5.307) | 0.171 |
Extent of resection GTR/non-GTR | 2.662 (0.767; 9.235) | 0.123 | 2.585 (0.908; 6.235) | 0.057 | 2.135 (0.933; 4.464) | 0.062 |