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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Isoaspartic acid is present at specific sites in myelin basic protein from multiple sclerosis patients: could this represent a trigger for disease onset?

Fig. 4

Deamidation of Gln147 in MBP from controls (●) and multiple sclerosis (MS) patients suffering from SPMS (○) PPMS (◊) and RRMS (▽). Deamidation of Gln147 was measured using the tryptic peptide GVDAQGTSK (i.e. GVDAQGTSK to GVDAEGTSK). Deamidation was significantly greater in the multiple sclerosis patients (p < 0.001, Mann–Whitney-U.). Deamidation increased with age in controls (R 2 = 0.571, p = 0.011)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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