Region | P8-15 (n) Neonatal | P28-35 (n) Pre-symptomatic | P65-75 (n) Onset | P120 (n) Mid-disease |
---|---|---|---|---|
Soma volume (μm3) | WT: 951.8 ± 263.4 (7) | WT: 1337.9 ± 150.1 (5) | WT: 1215.4 ± 205.2 (5) | WT: 860.1 ± 112.3 (8) |
SOD1: 1337.1 ± 216.9 (5) | SOD1: 1236.3 ± 267.4 (5) | SOD1: 1203.6 ± 266.1 (5) | SOD1: 773.5 ± 132.6 (12) | |
Not significant | Not significant | Not significant | Not significant | |
Total arbor length (μm) | WT: 1658 ± 119 (7) | WT: 2263 ± 175 (5) | WT: 2343 ± 190 (5) | WT: 2675 ± 321 (8) |
SOD1: 2446 ± 336 (5) | SOD1: 2074 ± 238 (5) | SOD1: 1243 ± 170 (5) | SOD1: 1294 ± 133 (12) | |
Adj. P = 0.09 | Adj. P > 0.99 | Adj. P = 0.01* | Adj. P < 0.0001**** | |
Apical arbor length (μm) | WT: 783 ± 145 (7) | WT: 1152 ± 84 (5) | WT: 912 ± 125 (5) | WT: 1378 ± 191 (8) |
SOD1: 1081 ± 204 (5) | SOD1: 1137 ± 221 (5) | SOD1: 564 ± 119 (5) | SOD1: 810 ± 197 (12) | |
Not significant | Not significant | Not significant | Not significant | |
Basal arbor length (μm) | WT: 915 ± 100 (7) | WT: 1111 ± 175 (5) | WT: 1430 ± 102 (5) | WT: 1296 ± 149 (8) |
SOD1: 1365 ± 225 (5) | SOD1: 937 ± 238 (5) | SOD1: 879 ± 88 (5) | SOD1: 484 ± 60 (12) | |
Adj. P = 0.048* | Adj. P > 0.99 | Adj. P = 0.0008*** | Adj. P < 0.0001**** | |
Mean basal tree length (μm) | WT: 233 ± 24 (7) | WT: 305 ± 9 (5) | WT: 350 ± 55 (5) | WT: 381 ± 32 (8) |
SOD1: 424 ± 93 (5) | SOD1: 273 ± 27 (5) | SOD1: 190 ± 17 (5) | SOD1: 133 ± 15 (12) | |
Adj. P = 0.004** | Adj. P > 0.99 | Adj. P = 0.03* | Adj. P < 0.0001**** | |
Apical reach (μm) | WT: 402 ± 58 (7) | WT: 517 ± 35 (5) | WT: 432 ± 32 (5) | WT: 573 ± 55 (8) |
SOD1: 355 ± 21 (5) | SOD1: 460 ± 63 (5) | SOD1: 372 ± 61 (5) | SOD1: 365 ± 32 (12) | |
Adj. P > 0.99 | Adj. P > 0.99 | Adj. P > 0.99 | Adj. P < 0.002** | |
Basal reach (μm) | WT: 207 ± 28 (7) | WT: 226 ± 25 (5) | WT: 248 ± 15 (5) | WT: 216 ± 14 (8) |
SOD1: 302 ± 56 (5) | SOD1: 192 ± 7 (5) | SOD1: 148 ± 20 (5) | SOD1: 135 ± 23 (12) | |
Not significant | Not significant | Not significant | Not significant | |
Apical ramifications | WT: 5.3 ± 0.8 (7) | WT: 5.9 ± 0.6 (5) | WT: 5.8 ± 0.4 (5) | WT: 6.9 ± 0.8 (8) |
SOD1: 7.5 ± 0.6 (5) | SOD1: 6.6 ± 0.9 (5) | SOD1: 5.5 ± 1.5 (5) | SOD1: 5.7 ± 0.8 (12) | |
Not significant | Not significant | Not significant | Not significant | |
Basal ramifications | WT: 3.2 ± 0.3 (7) | WT: 4.2 ± 0.5 (5) | WT: 4 ± 0.3 (5) | WT: 4.4 ± 0.2 (8) |
SOD1: 4.4 ± 0.3 (5) | SOD1: 4.2 ± 0.1 (5) | SOD1: 3.4 ± 0.4 (5) | SOD1: 3.1 ± 0.3 (12) | |
Not significant | Not significant | Not significant | Not significant | |
Apical spine density per 100 μm | WT: 21.1 ± 2.7 (7) | WT: 25.3 ± 1.1 (5) | WT: 33.8 ± 1.6 (5) | WT: 27.5 ± 1.6 (8) |
SOD1: 21 ± 3.4 (5) | SOD1: 20 ± 2.8 (5) | SOD1: 15.4 ± 2.5 (5) | SOD1: 19.6 ± 2.5 (12) | |
Adj. P > 0.9999 | Adj. P = 0.8341 | Adj. P = 0.0002*** | Adj. P = 0.0415* | |
Basal spine density per 100 μm | WT: 15.9 ± 1.7 (7) | WT: 22.4 ± 2.2 (5) | WT: 26.2 ± 1.6 (5) | WT: 22.1 ± 1.8 (8) |
SOD1: 18.4 ± 1.2 (5) | SOD1: 12.5 ± 1.4 (5) | SOD1: 14.3 ± 2.5 (5) | SOD1: 14.2 ± 1.6 (12) | |
Adj. P > 0.99 | Adj. P = 0.01* | Adj. P = 0.002** | Adj. P = 0.004** |