Table 1 Cortical thickness for the motor cortex, MPFC, somatosensory cortex and entorhinal cortex. All data presented as mean ± SEM
Region | P8-15 (n) Neonatal | P28-35 (n) Pre-symptomatic | P65-75 (n) Onset | P120 (n) Mid-disease |
|---|---|---|---|---|
Motor cortex | WT: 1057 ± 23.8 (7) | WT: 1494 ± 48.9 (5) | WT: 1440 ± 72.8 (5) | WT: 1487 ± 69.9 (8) |
SOD1: 1095 ± 38.2 (5) | SOD1: 1189 ± 112.9 (5) | SOD1: 1069 ± 62.5 (5) | SOD1: 1136 ± 40.4 (12) | |
Adj. P > 0.99 | Adj. P = 0.012* | Adj. P = 0.002** | Adj. P = 0.0005*** | |
MPFC | WT: 489 ± 38.8 (7) | WT: 645 ± 25.6 (5) | WT: 613 ± 36.2 (5) | WT: 697 ± 39.6 (8) |
SOD1: 495 ± 11.4 (5) | SOD1: 602 ± 53.7 (5) | SOD1: 541 ± 38.3 (5) | SOD1: 507 ± 21.2 (12) | |
Adj. P > 0.99 | Adj. P > 0.99 | Adj. P > 0.99 | Adj. P < 0.0001**** | |
Somatosensory cortex | WT: 995 ± 46.0 (7) | WT: 1259 ± 66.6 (5) | WT: 1223 ± 22.1 (5) | WT: 1211 ± 39.8 (8) |
SOD1: 1002 ± 22.3 (5) | SOD1: 1148 ± 26.0 (5) | SOD1: 1242 ± 40.2 (5) | SOD1: 997 ± 39.8 (12) | |
Adj. P > 0.99 | Adj. P = 0.49 | Adj. P > 0.99 | Adj. P = 0.0005*** | |
Entorhinal cortex | WT: 733 ± 38.1 (7) | WT: 960 ± 30.1 (5) | WT: 907 ± 28.7 (5) | WT: 956 ± 42.7 (8) |
SOD1: 785 ± 55.6 (5) | SOD1: 983 ± 78.6 (5) | SOD1: 904 ± 36.3 (5) | SOD1: 833 ± 57.8 (12) | |
Not Significant | Not Significant | Not Significant | Not Significant |