Skip to main content
Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Fig. 7

Decreased apical dendritic spine density of SOD1 LVPNs within the somatosensory cortex commencing from P65-75, compared to WT controls. Images show mosaics of somatosensory cortex LVPNs from P65-75 WT (a) and SOD1 (b) mice. High-magnification images of apical dendrites from P65-75 WT (c), SOD1 (d) and basal dendrites from P120 WT (e) and SOD1 (f) mice somatosensory cortex are also shown. Examples of apical and basal dendritic spines are identified with red arrowheads. g shows a scatterplot quantifying unchanged total dendritic arbor length (μm) of SOD1 LVPNs (grey squared) compared to WT controls (white circles). h shows a scatterplot quantifying unchanged apical arbor length (μm) of SOD1 LVPNs (grey squared) compared to WT controls (white circles). i shows a scatterplot quantifying significantly decreased apical dendritic spine density per 100 μm of SOD1 LVPNs (grey squared) compared to WT controls (white circles) at P65-75 and P120. All data mean ± SEM, with two-way ANOVAs followed by Bonferroni post-tests, *P < 0.05. n = 7, 5, 5 and 8 for WT P8-15, P28-35, P65-75 and P120 respectively. n = 6, 5, 5 and 12 for SOD1 P8-15, P28-35, P65-75 and P120 respectively. Scale bar: b, 50 μm. c and f, 5 μm

Back to article page

Acta Neuropathologica Communications

ISSN: 2051-5960

Contact us