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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Fig. 4

Decreased dendritic arbors of SOD1 LII-IIIPNs within the motor cortex at P120 and decreased apical spine density commenced from P8-15, compared to WT controls. Images show mosaics of motor cortex LII-IIIPNs from P120 WT (a) and SOD1 (b) mice. High-magnification images of apical dendrites from P8-15, P28-35, P65-75 and P120 WT (c, e, g, i) and SOD1 (d, f, h, j) motor cortex, with examples of dendritic spines indicated with open arrowheads, are also shown. k is a scatterplot quantifying significantly decreased total dendritic arbor length (μm) of SOD1 LII-IIIPNs (grey squared) compared to WT controls (white circles) at P120. l is a scatterplot quantifying significantly decreased apical arbor length (μm) of SOD1 LII-IIIPNs (grey squared) compared to WT controls (white circles) at P120. m is a scatterplot quantifying significantly decreased apical dendritic spine density per 100 μm of SOD1 LII-IIIPNs (grey squared) compared to WT controls (white circles) at P8-15, P28-35 and P65-75. All data are mean ± SEM, with two-way ANOVAs followed by Bonferroni post-tests, *P < 0.05, **P < 0.01 and ***P < 0.001; n = 7, 5, 5 and 8 for WT P8-15, P28-35, P65-75 and P120 respectively; n = 6, 5, 5 and 12 for SOD1 P8-15, P28-35, P65-75 and P120 respectively. Scale bar: b, 100 μm; j, 5 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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