Fig. 3From: Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1G93A mouse model of amyotrophic lateral sclerosisDecreased apical and basal dendritic spine density of SOD1 LVPNs within the motor cortex commenced from P28-35, compared to WT controls. High-magnification images of apical dendrites from P8-15, P28-35, P65-75 and P120 WT (a, c, e, g) and SOD1 (b, d, f, h) motor cortex are shown. High-magnification images of basal dendrites from P8-15, P28-35, P65-75 and P120 WT (i, k, m, o) and SOD1 (j, l, n, p) motor cortex are also shown. Examples of apical and basal dendritic spines are identified with red arrowheads. q is a scatterplot quantifying significantly decreased apical dendritic spine density per 100 μm of SOD1 LVPNs (grey squared) compared to WT controls (white circles) at P28-35, P65-75 and P120. r is a scatterplot quantifying significantly decreased basal dendritic spine density per 100 μm of SOD1 LVPNs (grey squared) compared to WT controls (white circles) at P28-35 and P65-75. All data are mean ± SEM, with two-way ANOVAs followed by Bonferroni post-tests, *P < 0.05 and **P < 0.01; n = 7, 5, 5 and 8 for WT P8-15, P28-35, P65-75 and P120 respectively; n = 6, 5, 5 and 12 for SOD1 P8-15, P28-35, P65-75 and P120 respectively. Scale bar: h and p, 3 μmBack to article page