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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Fig. 1

Cortical regions used for measuring thickness and for tracing neurons. Lines parallel or perpendicular to the axis of the midline (dotted lines) were used to measure: a the thickness of the motor cortex (mean of purple dashed arrows from the corpus callosum to the pia), the MPFC (means of the red dashed arrows from the corpus callosum to the midline), the somatosensory cortex (the length of the blue arrow from the lateral fork of the corpus callosum to the most lateral edge of the pia) and (b) the entorhinal cortex (the length of green arrow from the lateral border of the corpus callosum to the most lateral edge of the pia). a and b show the motor cortex (purple), MPFC (red), somatosensory cortex (blue) and entorhinal cortex (green) regions to be used to select neurons for dendritic morphology assessment were defined using the aid of a mouse brain atlas [21]

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Acta Neuropathologica Communications

ISSN: 2051-5960

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