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Table 3 Proteins differentially expressed between FTLD-TDP-GRNlτ and FTLD-TDPτ

From: Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation

Spot n° Protein name Accession No. Gene name p-value Fold change Theoretical pI/MW Apparent pI/MW Mascot score % sequence coverage
 308 Gelsolin P06396 GSN 0.001 +1.4 5.9/85 5.9/85 77 1.4
 436 Neurofilament light polypeptide P07196 NEFL 4.57E-04 - 1.5 4.5/61.5 4.5/61.5 202 34.3
Metabolism related proteins
 780 Glyceraldehyde-3-phosphate dehydrogenase (2) P04406 GAPDH 0.001 +1.3 8.6/36 8.4/36 63.5 21.2
 1040 Ferritin light subunit P02792 FTL 3.67E-06 +2.2 5.4/20 5.4/20 354.5 30.3
 738 Fructose 1.6 biphosphate aldolase P04075 ALDOA 0.0037 +1.2 9.2/39.4 9.2/39.4 81 33.5
 639 Alpha-enolase P06733 ENO1 1.57E-04 +1.9 7.7/47.1 7.7/47.1 178 44.5
 1033 Phosphatidylethanolamine-binding protein 1 P30086 PEBP1 0.007 +1.3 7.4/21 8.4/21 101 56.7
 956 Peroxiredoxin 6 P30041 PRDX6 1.94E-05 +1.9 6.3/25 7.0/25 147 52.2
 523 Pyruvate Kinase M (2) P14618 PKM 0.019 +1.2 9.0/60 8.4/60 93.9 31.8
 708 Phosphoglycerate kinase 1 P00558 PGK1 0.023 +1.2 9.2/45 9.2/45 95.2 29.5
 770 N(G).N(G)-dimethylarginine dimethylaminohydrolase 1 O94760 DDAH1 4.36E-04 +1.3 5.5/31.1 5.8/43 121 44.6
 838 Guanine nucleotide-binding protein 1 P62873 GNB1 7.02E-05 - 1.6 5.6/37 5.6/37 117 42.9
 714 Creatine Kinase B P12277 CKB 0.004 - 1.2 5.2/42.6 5.6/42.6 206 54.9
Astrocytic related proteins
 618 Glial fibrillary acidic protein (3) P14136 GFAP 2.43E-06 +3.2 5.3/49.8 5.5/49.8 287 56.4
 689 Glutamine synthetase P15104 GLUL 0.003 - 1.2 6.5/42 7.2/42 69.4 16.4
Synaptic related proteins
 476 Dihydropyrimidinase-related protein 2 (2) Q16555 DPYSL2 4.62E-04 - 1.3 5.9/62.3 6.6/62.3 274 50.1
 448 Syntaxin-binding protein 1 (2) P61764 STXB1 3.70E-04 - 1.3 6.5/67.5 7.6/60 138 22.6
Other
 883 Annexin 5 P08758 ANXA5 1.75E-04 +1.5 4.8/35.9 4.8/35.9 188 45.6
 976 Ubiquitin carboxyl-terminal hydrolase isoenzyme L1 P09936 UCHL1 0.003 - 1.3 5.2/25 5.2/25 85.8 47.1
 430 Heat shock 70 kDa protein 1A P0DMV8 HSPA1A 0.002 +1.3 5.4/70 5.4/60 110 27.9
  1. Data obtained from Samespot software are presented for each spot of interest: spot number, p-value, fold change (FTLD-TDP-GRNlτ vs FTLD-TDPτ), experimental molecular weight (MW) and isoelectric point (pI). According to mass spectrometry identification of each protein, table also gives: the protein full name, accession number, gene name, mascot score, sequence coverage (%), and the theoretical molecular weight (MW) and pI of the non-modified protein. A mascot score above 61 was considered as significant for protein identification. Difference between theoretical and experimental molecular weight or pI is underlined. Number of isovariants for each protein spot is indicated with the protein name (see parenthesis)