Fig. 2
APPSWE/PS1ΔE9 x IFNAR1−/− mice are spared from cognitive impairment. Wildtype, IFNAR1−/−, APPSWE/PS1ΔE9 and APPSWE/PS1ΔE9 x IFNAR1−/− littermate controls 9 months of age were subjected to Morris water maze testing to assess spatial learning and memory. All mice were tested using a 7-day hidden platform acquisition (4trials/day) with probe trial protocol as described in Materials and Methods. Primary water maze readouts of a average trial latency, b trial success rate and c trial path length (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, WT vs. APPSWE/PS1ΔE9; θp < 0.05, θθp < 0.01, θθθp < 0.001, θθθθp < 0.0001, WT vs. APPSWE/PS1ΔE9 x IFNAR1−/−; +p < 0.05, ++p < 0.01, +++p < 0.001 WT vs. IFNAR1−/−). d Representative automated tracks from day 7 testing is shown for all genotypes. e After day 7 acquisition the escape platform is removed from the maze and mice are introduced into the maze for a final trial. Quantification of the time spent in the platform containing quadrant for all genotypes is shown. The dashed line (y = 25 %) represents the percentage of time spent in the escape quadrant that would be solely due to random chance as opposed to preference (p < 0.05). f Calculation of average swim velocity across all 7 days of testing is shown for all genotypes (**p < 0.01). Data is displayed as mean ± SEM or box plots described in the statistical analysis section in Materials and Methods (n = 14 (APPSWE/PS1ΔE9), n = 9 (APPSWE/PS1ΔE9 x IFNAR1−/−), n = 18 (IFNAR1−/−), n = 15 (wildtype)). See Additional file 2: Table S1 for further analysis