Fig. 2
From: From animal models to human disease: a genetic approach for personalized medicine in ALS
Clinical findings in Amyotrophic lateral sclerosis (ALS). Signs and symptoms are divided by affected motor neuron. Both upper motor neurons (UMN) and lower motor neurons (LMN) have to be affected for the diagnosis of ALS. Different combination of LMN and UMN signs can be observed. Limb onset is found in around 65Â % of patients but most patients will develop signs in both bulbar region and limbs within the course of disease. Up to 50Â % of ALS patients may have symptoms of Fronto-Temporal dementia