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Table 2 Results for two proposed models of C3’s effect on ptau in which amyloid mediates the effect of C3 on ptau (Model A) and in which C3 and amyloid act synergistically on ptau (Model B)

From: The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer’s disease

Model Analysis Outcome Variable Estimate ± SE P-value
Model A I CSF ptau Age −0.32 ± 0.2 0.05
Sex −2.41 ± 2.3 0.29
CDR-SB 3.35 ± 0.6 7.25 × 10−8
C3 6.10 ± 6.5 0.35
II CSF ptau Age −0.22 ± 0.1 0.14
Sex −1.15 ± 2.05 0.58
CDR-SB 1.67 ± 0.6 5.01 × 10−3
C3 12.11 ± 5.9 0.04
CSF amyloid −0.14 ± 0.02 4.97 × 10−12
Model B I CSF ptau Age −0.25 ± 0.15 0.10
Sex −1.11 ± 2.1 0.59
CDR-SB 1.70 ± 0.6 4.47 × 10−3
C3 27.7 ± 19.6 0.16
CSF amyloid −0.38 ± 0.3 0.19
C3:CSF amyloid −0.09 ± 0.1 0.41
  1. SE standard error
  2. An illustration of the two models is provided in Fig. 3. Estimates are β estimates from a multiple regression model which included age, sex, and baseline CDR-SB score as covariates