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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer’s disease

Fig. 3

Two possible models for the relationship between C3, amyloid, and ptau. Two possible models for the effects of C3, amyloid β, and APOE ε4 on ptau are illustrated as A and B. Solid arrows represent main effects of each variable and dotted arrows represent the interaction effect of two variables, all assessed in multivariate linear models which included age, sex, and CDR-SB score as covariates. Results for the two illustrated models are in Table 2. a Model A hypothesizes that C3’s effect on ptau will be mediated by amyloid. Roman numerals represent the following effects: (I) direct effect of C3 to predict ptau and (II) the hypothesized mediating effect of amyloid when added to the model in (I). b Model B suggests an alternate relationship whereby C3 and amyloid act synergistically to alter ptau. Roman numeral (I) corresponds to a hypothesized statistical interaction between C3 and amyloid to predict ptau levels

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