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Table 1 Summary of iPSCs in this study

From: Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes

clone name

clinical character

GFAP genotype

Sex

Age at onset

Age at sampling

HC1

healthy

wild

female

-

36

HC2

healthy

wild

female

-

67

HC3

healthy

wild

male

-

74

Alex1

Alexander disease type I

R239C (c. 729 C > T)

male

2

6

Alex2

Alexander disease type I

E63K (c.205 G > A)

female

3

10

Alex3

Alexander disease type II

R276L (c.827 G > T)

female

33

45

  1. Abbreviations: GFAP Glial fibrillary acidic protein, HC Healthy control
  2. Alex1 was generated from patient fibroblasts (GM16825) from Coriell Institute (Camden, NJ)