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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes

Fig. 3

Astrocytes of Alexander disease showed GFAP-positive aggregates. a Most iPSC-derived astrocytes showed GFAP-positive staining (green color). In healthy control, GFAP showed filamentous structure. In Alexander disease, GFAP mainly showed filamentous structure, but also fibrous/amorphous (arrows) or dot-like (arrowheads) aggregates. Scale bars = 5 μm. b Calculated purity of astrocytic differentiation data represent mean ± SD (biological replicates, n = 3 from randomly picked fields per clone). c Calculated positivity of GFAP aggregates. Data represent mean ± SD (biological replicates, n = 3 from randomly picked fields per clone)

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