Fig. 3
From: Increased tauopathy drives microglia-mediated clearance of beta-amyloid
The combination of Aβ and tau pathology alters the production of cytokines within the brain. MSD multiplex ELISA was utilized to examine several key cytokines. Compared to WT, Tau and 5xfAD littermates, T5x mice showed a significant increase in both TNF-α and IL-2 (p < 0.0001). In contrast, T5x mice exhibited a significant decrease in IL-1β in comparison to 5xfAD littermates (p < 0.0001) as well as decreases in IL-5, IL-6, and IL-10 (p < 0.05). Data are represented as mean ± SEM, n ≥ 8 mice/group. * Indicates p < 0.05 for both ANOVA and Fisher’s protected least-significant difference (PLSD) post hoc tests with significance versus all other groups, whereas *over a bar indicates significance between 2 or 3 particular groups