Skip to main content

Table 2 Pathologic features and phosphorylated TDP-43 pathology in three types of sporadic ALS

From: Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes

  Type 1 Type 2a Type 2b P-value
  (n = 63) (n = 22) (n = 11)  
Neuronal lossa     
 Motor cortex 2.1 ± 0.7 2.1 ± 0.7 2.5 ± 0.7 0.073
 Anterior horns (cervical and lumbar) 2.2 ± 0.5 2.1 ± 0.6 1.5 ± 0.4* 0.002
 Hypoglossal nucleus 2.3 ± 0.7 2.1 ± 0.7 1.4 ± 0.5** <0.001
 Frontotemporal degeneration (cases) 4 (6 %)*** 8 (36 %) 7 (64 %) <0.0001
pTDP-43 pathology (cases)     
 NCIs: temporal-predominant type NA 13 (59 %) 5 (45 %) NA
 DNs: many in neostriatum and globus pallidus 1 (2 %) 2 (9 %) 9 (82 %)**** <0.0001
  1. ALS amyotrophic lateral sclerosis, pTDP-43 phosphorylated TDP-43, NCI neuronal cytoplasmic inclusion, DN dystrophic neurite, NA non-applicable
  2. a0 = absent, 1 = mild, 2 = moderate, 3 = severe. Data are expressed as mean ± standard deviation
  3. *P <0.001 vs. Type 1 and P = 0.018 vs. Type 2a, **P = 0.001 vs. Type 1 and P = 0.022 vs. Type 2a (Kruskal-Wallis test with post-hoc Steel-Dwass test), ***P <0.001 vs. Type 2a and P = 0.00001 vs. Type 2b (Fisher’s exact test with Ryan’s multiple comparison test), ****P <0.00001 vs. Type 1 and P <0.0001 vs. Type 2a (Fisher’s exact test with Ryan’s multiple comparison test)