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Table 2 Pathologic features and phosphorylated TDP-43 pathology in three types of sporadic ALS

From: Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes

 

Type 1

Type 2a

Type 2b

P-value

 

(n = 63)

(n = 22)

(n = 11)

 

Neuronal lossa

    

 Motor cortex

2.1 ± 0.7

2.1 ± 0.7

2.5 ± 0.7

0.073

 Anterior horns (cervical and lumbar)

2.2 ± 0.5

2.1 ± 0.6

1.5 ± 0.4*

0.002

 Hypoglossal nucleus

2.3 ± 0.7

2.1 ± 0.7

1.4 ± 0.5**

<0.001

 Frontotemporal degeneration (cases)

4 (6 %)***

8 (36 %)

7 (64 %)

<0.0001

pTDP-43 pathology (cases)

    

 NCIs: temporal-predominant type

NA

13 (59 %)

5 (45 %)

NA

 DNs: many in neostriatum and globus pallidus

1 (2 %)

2 (9 %)

9 (82 %)****

<0.0001

  1. ALS amyotrophic lateral sclerosis, pTDP-43 phosphorylated TDP-43, NCI neuronal cytoplasmic inclusion, DN dystrophic neurite, NA non-applicable
  2. a0 = absent, 1 = mild, 2 = moderate, 3 = severe. Data are expressed as mean ± standard deviation
  3. *P <0.001 vs. Type 1 and P = 0.018 vs. Type 2a, **P = 0.001 vs. Type 1 and P = 0.022 vs. Type 2a (Kruskal-Wallis test with post-hoc Steel-Dwass test), ***P <0.001 vs. Type 2a and P = 0.00001 vs. Type 2b (Fisher’s exact test with Ryan’s multiple comparison test), ****P <0.00001 vs. Type 1 and P <0.0001 vs. Type 2a (Fisher’s exact test with Ryan’s multiple comparison test)