Fig. 4
From: Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease
Compared to controls (a, Rh1-GAL4 / +), TEM reveals modest ultrastructural defects in rhabdomeres of Rh1 > Tau b, Rh1 > Aß c and Rh1 > αSyn d flies at 10 days. a Photoreceptor subcellular organelles are labelled, including nucleus (n), rhabdomere (r), mitochondria (m), and rough endoplasmic reticulum (e). Non-neuronal pigment (p) cells and glia (g) are also noted. e Frequency of photoreceptors with rhabdomere structural defects was quantified from electron micrographs taken from 3 distinct animals per genotype. Total number photoreceptors quantified (genotype, n): Rh1-GAL4/+, 614; Rh1 > Aß, 326; Rh1 > Tau, 389; and Rh1 > αSyn, 330. Scale bar: 1 μm. Statistical comparisons were implemented using a two-tailed student’s t-test. *, p < 0.05; **, p < 0.01; ***, p < 0.001