Table 1 NHERF1 and NF2 in the differential diagnosis of papillary tumors of the CNS
From: NHERF1/EBP50 and NF2 as diagnostic markers for choroid plexus tumors
Diagnosis | Patients | IHC | |||||
|---|---|---|---|---|---|---|---|
No. cases Gender | Median age (range, yrs) | Location | NHERF1 | NF2 | |||
4thV | 3rdV | LV | |||||
CPP Adult | 13 (6 F, 5 M) | 43 (20–73) | 121 | 1 | 0 | Apical PM | Basolateral and apical PM |
CPP Pediatric | 9 (4 M, 5 F) | 0.5 (0.25-6) | 1 | 2 | 6 | Apical PM | Basolateral and apical PM |
aCPP Adult | 2 (1 M, 1 F) | 40 (35, 46) | 2 | 0 | 0 | Cyt, variable2; | Basolateral and apical PM |
aCPP Pediatric | 4 (2 M; 2 F) | 0.7 (0.3-1.6) | 0 | 0 | 4 | Cyt, apical PM | Basolateral and apical PM |
CPC Adult | 1 (1 F) | 37 | 1 | 0 | 0 | Cyt or absent | Basolateral and apical PM |
CPC Pediatric | 3 (2 M, 1 F) | 1.7 (1, 2) | 0 | 0 | 3 | Cyt or absent | Basolateral and apical PM |
PTPR | 5 (3 M, 2 F) | 40 (33–62) | 0 | 5 | 0 | Microlumens, apical PM | Cytoplasmic, membranous |
Metastases3 | 6 (4 F, 2 M) | 65 (43–73) | Apical PM | Absent, apical PM, nuclear | |||