Fig. 4
From: NHERF1/EBP50 and NF2 as diagnostic markers for choroid plexus tumors
Mixed apical plasma membrane and microlumen NHERF1 labeling pattern in PTPR. a H& E of PTPR1 case shows typical multilayered papillary histology. IHC with NHERF1 antibody shows a characteristic mixed labeling pattern with focal apical plasma membrane staining (arrows) and microlumens (right panel). b H& E in PTPR4 shows densely cellular multi-layered papillae with areas of necrosis (arrow). Compact areas have many mitoses, including atypical ones (arrowhead in inset), and ependymal morphology, including true rosettes, also highlighted by NHERF1 IHC (red arrows)