Fig. 3

Clinico-pathologic correlates in two adult patients with atypical CP papilloma (aCPP). a Distinct patterns of NHERF1 IHC in two aCPP adult cases, labeling the cytoplasm, in aCPP1, and rings and microlumens in compact areas, in aCPP2. NF2 IHC has membrane staining in both cases, which helps cueing the CP origin of the tumors. The arrow indicates a mitotic figure in aCPP2. b Time course of clinical events shows disease onset, surgical interventions and pathologic diagnosis in red, and radiologic progression or death in black. The survival is shown in blue. aCPP1 is alive at the time of this analysis, with wide CNS dissemination, including the lumbar spinal cord. Note sequential progression from CP papilloma (CPP) to aCPP in aCPP2