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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Notch1 hallmarks fibrillary depositions in sporadic Alzheimer’s disease

Fig. 6

Intracellular depositions of Notch1 and p-Tau are increased in AD degenerating neurons. aa’) Double immunostaining showing the enhanced number of damaged neurons labeled with p-Tau and partially with Notch1 in AD and healthy control cortical tissue. b) Triple staining showing the co-expression of Notch1 and p-Tau in neurofilament positive degenerating cortical neurons (insert). cd) Bar graphs indicating the counting of degenerating neurons positive for p-Tau or double positive for p-Tau and Notch1, either in the hippocampus (c) or in the entorhinal cortex (d). *= p<0.05, **= p<0.01, Error bars are SEM. Scale bar in (a’) is 100 μm and in (b) 40 μm

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