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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Notch1 hallmarks fibrillary depositions in sporadic Alzheimer’s disease

Fig. 4

Notch1 distribution in Thioflavin T positive plaques and fibrillary aggregates. aa”) Double immunofluorescence indicates the co-expression of Notch1 and Thioflavin T stained fibrils in AD brains (a’-a") as compared to the age matched control (a). In non-demented patients, Notch1 is homogeneously distributed in neurons and Thioflavin T signal is not present. b and c) Bar graphs showing the counting, of single or double labeled plaques for Notch1 and Thioflavin T in the hippocampus (b) and in the entorhinal cortex (c). d-d’) Fluorescence immunostaining of the entorhinal cortex for Notch1, APP and Thioflavin T shows that Notch1 is mainly localized with Thioflavin T deposits (arrows in d’ and insert) and to a lower extent with APP in AD brains. Expression of Notch1 and APP is critically altered in AD brains as compared to healthy control tissue (d). **= p<0.01. Error bars are SEM. Scale bars are 50 μm in all images

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