Fig. 10

Altered Notch1 expression and deposition in the liver of AD patients. a-b) Immunofluorescence on liver sections. a) Notch1 and A β42 positive aggregates (arrows) in the hepatic parenchyma of AD patients, but not in controls. Moreover, Notch1 is highly expressed in the cytosol of several hepatocytes (arrowsheads). b) Antibodies specific for the extracellular and intracellular portions of Notch1 strongly label hepatocytes in the AD liver as compared to the healthy control section. c) Box plot summarizing the mean grey value intensity of the Notch1 intracellular signal in AD and CTL hepatocytes. d) Box plot summarizing the mean grey value intensity of the Notch1 extracellular signal in AD and CTL hepatocytes. The scale bars are in (a) and (b) 50 μm