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Table 2 Structural remodelling of Purkinje cell axons in both FRDA and control cases

From: Purkinje cell injury, structural plasticity and fusion in patients with Friedreich’s ataxia

Axonal change Comparator Control cases (Mean +/-SE (median)) FRDA cases (Mean +/-SE (median)) Significance (p value)
Hypertrophic axons Length 0.279 +/- 0.216 (0.298) 1.642 +/- 0.659 (1.028) p < 0.010
  Purkinje cells 0.016 +/- 0.007 (0.010) 0.054 +/- 0.018 (0.036) p < 0.050
Hypertrophic recurrent collaterals Length 0.115 +/- 0.038 (0.118) 0.457 +/- 0.143 (0.396) p < 0.050
  Purkinje cells 0.003 +/- 0.001 (0.003) 0.015 +/- 0.004 (0.011) p < 0.050
Arciform fibres Length 0.029 +/- 0.014 (0.023) 0.158 +/- 0.052 (0.138) p < 0.050
  Purkinje cells 0.001 +/- 0.001 (0.001) 0.005 +/- 0.001 (0.004) p < 0.050
Axonal branching Length 0.064 +/- 0.024 (0.060) 0.271 +/- 0.088 (0.261) p = 0.082
  Purkinje cells 0.002 +/- 0.001 (0.002) 0.009 +/- 0.003 (0.006) p < 0.050
Axonal sprouting Length 0.062 +/- 0.027 (0.060) 0.226 +/- 0.078 (0.172) p = 0.052
  Purkinje cells 0.002 +/- 0.001 (0.002) 0.006 +/- 0.001 (0.007) p < 0.050
  1. The frequency of axonal structural changes within the granular and Purkinje cell layers of both control and FRDA cases. All axonal changes are expressed as either frequency per standardized unit length of the Purkinje cell layer (100 μm) (Length) or frequency per Purkinje cell (Purkinje cells). Comparisons between control and FRDA were analysed using Mann-Whitney U tests