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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Purkinje cell injury, structural plasticity and fusion in patients with Friedreich’s ataxia

Fig. 6

Microglial numbers within cerebellar grey matter regions positively correlate with the incidence of bi-nucleate Purkinje cells. a Levels of HLA-DP, DQ, DR positive cells within the cerebellar white and grey matter regions of FRDA and control cases. b Representative images of HLA-DP, DQ, DR positive cells (DAB (brown) immuno-labelled and counterstained with haematoxylin (blue)) within the cerebellar folia of FRDA and control cases. The dashed inset is a higher magnified image depicting microglial morphology in a FRDA case showing microglia with both enlarged perikarya and thicker processes. c Correlations and linear regression analysis between microglial cell numbers (in both the white matter and grey matter) and the frequency of total bi-nucleate Purkinje cells, bi-nucleate Purkinje cells with two large Purkinje cell-like nuclei (Big/Big) or bi-nucleate Purkinje cells with one large Purkinje cell-like nucleus and one smaller nucleus with compact chromatin (Big/Small). Results are expressed as the mean +/- (SE). R 2 = Pearson’s correlation coefficient of determination. (ns (not significant), comparing FRDA to control)

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