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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Purkinje cell injury, structural plasticity and fusion in patients with Friedreich’s ataxia

Fig. 2

Abnormal neurofilament phosphorylation within Purkinje cell axons in FRDA. a A representative image of the cerebellar folia from an FRDA case showing Calbindin-D28K positive hypertrophic axons and axonal torpedoes expressing high levels of SMI-34. The hatched areas in (i) represents the higher magnified images (ii/iii). White arrows in (i) indicate areas of Calbindin-D28K/SMI-34 co-expression. b 3-dimensional confocal image of a Purkinje cell immunofluorescently labelled with Calbindin-D28K (green), SMI-34 (red) and DAPI nuclear stain (blue) (perikaryon (white triangle/asterisk), axonal torpedo (white triangle), recurrent collateral (white arrow)). The hatched areas in (i) represents the higher magnified images (ii/iii). c Quantification of SMI-34 positive torpedoes per Purkinje cell in FRDA and control cases. Results are expressed as the mean +/- (SE) (*p < 0.05, comparing FRDA to control)

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