Fig. 8

Cerebellar histologic sections immunostained with TDP43 (a-d). In the 61 year-old proband’s brain, dentate nucleus neurons show nuclear staining (a), while Purkinje cells show cytoplasmic staining but lack nuclear staining (b). In brain sections from 60 year-old (c) and 89 year-old (d) control subjects, Purkinje cells demonstrate nuclear staining with variable degrees of cytoplasmic staining. (polyclonal TDP43, 1:1000, Proteintech; original magnifications ×400)