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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C

Fig. 5

a Immunofluorescence of the stress granule marker TIA-1 in wt (a) and NPC (b) neuron-like cells. Arrows indicate the cytosolic localization of stress granules in NPC cells. c Quantitative evaluation of the percentage of neuron like cells displaying cytoplasmic localization of TIA- in wt (n = 4) and NPC patients (n = 4). At least 400 cells have been counted for each cell line. Data are presented as mean ± SD of 3 independent experiments. **p < 0.01 in Student’s t test. d-g Co-immunofluorescence of TIA-1 and TDP-43 in NPC neuronal-like cells. Arrows indicate colocalization. Nuclei were stained with DAPi (blue)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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