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Table 3 Clinical characteristics and outcome per genotype in 396 white patients with community-acquired pneumococcal meningitisa

From: V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis

Characteristic GG (n = 195) AG (n = 162) AA (n = 39) p-value recessive model
Age 58 ± 14 60 ± 13 56 ± 17  
Gender 86 (44 %) 79 (49 %) 17 (44 %) 0.63
Glasgow Coma Scale Score 11 ± 3 11 ± 3 9 ± 3 0.006
Seizures on admission 12/188 (7 %) 10/158 (6 %) 6/36 (17 %) 0.024
Fever 168 (86 %) 123 (76 %) 26 (67 %) 0.019
Focal neurologic abnormalities 43 (22 %) 58 (36 %) 14 (36 %) 0.28
Leukocytes <1000 50 (26 %) 52 (32 %) 13 (36 %) 0.36
Respiratory failure 39/191 (21 %) 44/157 (29 %) 13 (33 %) 0.29
Mechanical ventilation 56/186 (30 %) 64/158 (41 %) 18/38 (47 %) 0.19
Seizures during admission 25/192 (14 %) 27/154 (18 %) 5/39 (13 %) 0.76
Focal neurologic deficit during admission 44/188 (23 %) 38/155 (24 %) 15/37 (41 %) 0.02
Unfavourable outcome 57/195 (29 %) 52/162 (32 %) 22/38 (58 %) 0.001
Death 12/195 (6 %) 13/162 (8 %) 4/38 (11 %) 0.43