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Table 3 Clinical characteristics and outcome per genotype in 396 white patients with community-acquired pneumococcal meningitisa

From: V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis

Characteristic

GG (n = 195)

AG (n = 162)

AA (n = 39)

p-value recessive model

Age

58 ± 14

60 ± 13

56 ± 17

 

Gender

86 (44 %)

79 (49 %)

17 (44 %)

0.63

Glasgow Coma Scale Score

11 ± 3

11 ± 3

9 ± 3

0.006

Seizures on admission

12/188 (7 %)

10/158 (6 %)

6/36 (17 %)

0.024

Fever

168 (86 %)

123 (76 %)

26 (67 %)

0.019

Focal neurologic abnormalities

43 (22 %)

58 (36 %)

14 (36 %)

0.28

Leukocytes <1000

50 (26 %)

52 (32 %)

13 (36 %)

0.36

Respiratory failure

39/191 (21 %)

44/157 (29 %)

13 (33 %)

0.29

Mechanical ventilation

56/186 (30 %)

64/158 (41 %)

18/38 (47 %)

0.19

Seizures during admission

25/192 (14 %)

27/154 (18 %)

5/39 (13 %)

0.76

Focal neurologic deficit during admission

44/188 (23 %)

38/155 (24 %)

15/37 (41 %)

0.02

Unfavourable outcome

57/195 (29 %)

52/162 (32 %)

22/38 (58 %)

0.001

Death

12/195 (6 %)

13/162 (8 %)

4/38 (11 %)

0.43