Skip to main content

Table 2 Novel SNPs associated with unfavorable outcome in patients with pneumococcal meningitis

From: V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis

Gene

Chr

Variation type

dbSNIPID

BP

Alleles

Allele frequency

P

BONF_P

OR (+/− 95 CI)

     

Effectd

Othere

UF

F

   

DCTN4 a

5

Upstream gene variant

rs6869603b

150142849

G

A

0.07

0.01

2.4 Ă— 10−05

1

5.6 (2.4–12.9)

DCTN4

5

F349L, F342L, F285L

rs11954652b

150097883

G

C

0.07

0.01

2.4 Ă— 10−05

1

5.6 (2.4–12.9)

RAET1E

6

E89E, E53E

rs3798763c

150211100

G

A

0.37

0.23

9.4 Ă— 10−05

1

1.9 (1.4–2.6)

RAET1E

6

R128H, R92H

rs6925151c

150210723

G

A

0.37

0.23

9.4 Ă— 10−05

1

1.9 (1.4–2.6)

AKT3

1

Silent

rs10157763

243995041

A

G

0.40

0.26

9.9 Ă— 10−05

1

1.9 (1.4–2.6)

  1. BP denotes base pair, UF unfavourable outcome, F favourable outcome
  2. a Variation within a regulatory area of this gene
  3. b,c Markers in linkage disequilibrium (LD)
  4. d Risk allele associated with unfavorable outcome
  5. e Allele without risk