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Table 2 Novel SNPs associated with unfavorable outcome in patients with pneumococcal meningitis

From: V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis

Gene Chr Variation type dbSNIPID BP Alleles Allele frequency P BONF_P OR (+/− 95 CI)
      Effectd Othere UF F    
DCTN4 a 5 Upstream gene variant rs6869603b 150142849 G A 0.07 0.01 2.4 × 10−05 1 5.6 (2.4–12.9)
DCTN4 5 F349L, F342L, F285L rs11954652b 150097883 G C 0.07 0.01 2.4 × 10−05 1 5.6 (2.4–12.9)
RAET1E 6 E89E, E53E rs3798763c 150211100 G A 0.37 0.23 9.4 × 10−05 1 1.9 (1.4–2.6)
RAET1E 6 R128H, R92H rs6925151c 150210723 G A 0.37 0.23 9.4 × 10−05 1 1.9 (1.4–2.6)
AKT3 1 Silent rs10157763 243995041 A G 0.40 0.26 9.9 × 10−05 1 1.9 (1.4–2.6)
  1. BP denotes base pair, UF unfavourable outcome, F favourable outcome
  2. a Variation within a regulatory area of this gene
  3. b,c Markers in linkage disequilibrium (LD)
  4. d Risk allele associated with unfavorable outcome
  5. e Allele without risk