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Table 1 Clinical characteristics of 472 patients with community-acquired pneumococcal meningitisa

From: V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis

Characteristic   Characteristic  
Age – yr 58 ± 15 Indexes of CSF inflammationc  
Male sex – no (%) 221 (47 %)  Opening pressure (mm H2O) 42 ± 11
Duration of symptoms <24 h 225/461 (49 %)  White blood cell count (/mm3) 2417 ± 5648
Pretreatment with antibiotics 58/459 (13 %)   <1.000/mm3 130/454 (29 %)
Predisposing conditions 322/472 (68 %)  Protein – g/L 4.7 ± 3.2
Otitis or sinusitis 218/471 (46 %)  CSF: blood glucose ratio 0.13 ± 0.18
Immunocompromised 124/472 (26 %) Positive blood cultures 337/420 (80 %)
Symptoms and signs on presentationb   Complications  
Headache 363/427 (85 %)  Cardiorespiratory failure 170/466 (36 %)
Neck stiffness 356/454 (78 %)  Focal neurologic deficits 109/455 (24 %)
Epileptic seizures 33/454 (7 %)  Epileptic seizures 69/460 (15 %)
Systolic blood pressure – mmHg 149 ± 29 Score on Glasgow Outcome Scale  
Heart rate – beats/min 100 ± 21  1 – death 37 (8 %)
Body temperature – °C 38.8 ± 1.3  2 – vegetative state 1 (0.2 %)
Score on Glasgow Coma Scalec 11 ± 3  3 – severe disability 23 (5 %)
<8 indicating coma 63/472/87 %)  4 – moderate disability 90 (19 %)
Focal neurologic deficits 109/455 (25 %)  5 – good recovery 321 (68 %)
  1. a Data are number/number evaluated (percentage), continuous data are mean ± SD. bSystolic blood pressure was evaluated in 469 patients, heart rate in 466, temperature in 471. cCSF opening pressure was evaluated in 165 patients, CSF WBC count in 454 patients, CSF protein in 452, CSF blood: glucose ratio in 452