Fig. 3
Histopathology during experimental S. pneumoniae meningitis. a-e Representative haematoxylin and eosin and f caspase-3- stained sections of a wild-type brain infected with 1 × 104 colony-forming units (CFU) of S. pneumoniae serotype 3, strain 6303 via intracisternal inoculation (24 h post inoculation). a Red asterisks show parenchymal infiltration of neutrophils. Arrows indicate b inflammation of and destruction of meningeal vessel, c parenchymal bleeding, d thrombosis in meningeal vessel, e apoptotic cell with pyknotic nucleus in the dentate gyrus of hippocampus and f caspase-3 positive cells in the dentate gyrus of hippocampus