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Table 8 Over-represented pathways in 0.05Pa-loaded or 0.05Pa + turbulent flow-loaded group compared with 3.0Pa-loaded group

From: Sustained expression of MCP-1 by low wall shear stress loading concomitant with turbulent flow on endothelial cells of intracranial aneurysm

Comparison Peaks REACTOME ID Pathway P-value FDR
3.0Pa < 0.05Pa + TF Top peaks REACT_7970 Telomere Maintenance 7.53E-12 1.36E-10
   REACT_8017 APC-Cdc20 mediated degradation of Nek2A 3.74E-03 2.32E-02
   REACT_152 Cell Cycle, Mitotic 3.86E-03 2.32E-02
  Bottom peaks REACT_7970 Telomere Maintenance 2.67E-14 4.01E-13
   REACT_152 Cell Cycle, Mitotic 8.97E-03 6.73E-02
3.0Pa < 0.05Pa Top peaks REACT_7970 Telomere Maintenance 5.21E-08 5.21E-07
   REACT_383 DNA Replication 2.24E-02 1.12E-01
   REACT_1538 Cell Cycle Checkpoints 8.86E-02 2.48E-01
   REACT_6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 1.20E-01 2.48E-01
   REACT_152 Cell Cycle, Mitotic 1.35E-01 2.48E-01
   REACT_8017 APC-Cdc20 mediated degradation of Nek2A 1.49E-01 2.48E-01
  Bottom peaks REACT_7970 Telomere Maintenance 1.16E-06 6.96E-06
   REACT_152 Cell Cycle, Mitotic 1.03E-02 3.09E-02
   REACT_383 DNA Replication 3.15E-02 6.30E-02
  1. FDR false discovery rate