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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Sustained expression of MCP-1 by low wall shear stress loading concomitant with turbulent flow on endothelial cells of intracranial aneurysm

Fig. 4

Induction of MCP-1 in the endothelial cell layer during intracranial aneurysm formation in rats. a, Representative image to show the anatomical structure of the bifurcation site of the intracranial artery. A merged image of immunohistochemistry for smooth muscle marker, α-smooth muscle actin (SMA, red), an endothelial cell marker, CD31 (green), and nuclear staining by DAPI (blue) is shown. White arrows indicate the direction of blood flow. Scale bar = 50μm. b and c, Expression of MCP-1 (b) and CX3CL1 (c) in the endothelial cell layer of arterial walls during IA formation. Immunohistochemistry for MCP-1 (green in b), CX3CL1 (green in c), SMA (red), and for the merged images with DAPI (blue) are shown. Scale bar = 50μm

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