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Table 2 Subject characteristics of TDP-43, α-synuclein and off-target binding studies

From: An autoradiographic evaluation of AV-1451 Tau PET in dementia

Case

Clinical diagnosis

Neuropathologic diagnosis

TDP type

Tau isoform

Braak

Thal

Age

Sex

Fig.

TDP-43

 6

svPPA

AD (HpSp)/DLBD

0

3R + 4R

VI

5

60

M

 

 29

svPPA

AD

0

3R + 4R

VI

5

77

M

Fig. 7 A-C

 30

agPPA

FTLD-TDP/HpScl (GRN)

A

--

0

0

64

M

Fig. 7 D-F; Fig. 8 D-I

 31

FTD

FTLD-TDP/HpScl (GRN)

A

--

0

0

63

M

Fig. 7G-I

 32

svPPA

FTLD-TDP

C

--

0

1

75

M

Fig. 7 J-L

 33

agPPA

FTLD-TDP

C

--

I

1

65

M

 

 16

svPPA

PiD

0

3R

0

0

74

M

 

α-Synuclein

 34

DLB

DLBD

0

--

0

0

60

M

 

 35

AD v DLB

DLBD

0

--

II-III

1

76

M

 

 36

MSA

MSA (SND & OPCA)

0

--

0

1

58

F

 

Off-target

 1

Normal

Normal

0

--

0

0

81

F

Fig. 9 A,B

 3

Normal

Normal

0

--

0

0

65

M

Fig. 9 C,D

 19

PSP

PSP

0

4R

II-III

1

68

F

Fig. 9 E,F

 6

svPPA

AD (HpSp)/DLBD

0

3R + 4R

VI

5

60

M

Fig. 9 G,H

 36

MSA

MSA (SND & OPCA)

0

--

0

1

58

F

Fig. 9 I,J

 30

agPPA

FTLD-TDP/HpScl (GRN)

A

--

0

0

64

M

Fig. 9 K,L

 2

Normal

Normal

0

--

0

0

68

M

Fig. 9 M-P

 31

FTD

FTLD-TDP/HpScl (GRN)

A

--

0

0

63

M

Fig. 9 Q-T

 37

CBD

NBIA

0

3R + 4R

V

0

51

M

 

 38

VaP

Siderosis

0

--

0

0

59

F

 
  1. De-identified case numbers are referred to throughout the text and within Figs. TDP-43 type was performed using the recommended harmonized classification system [33]. Braak refers to neurofibrillary tangle stage [29] and Thal refers to amyloid phase [37]. Abbreviations: svPPA semantic variant of primary progressive aphasia, agPPA agrammatic variant of PPA, FTD frontotemporal dementia, DLB dementia with Lewy bodies, AD Alzheimer’s disease, MSA multiple systems atrophy, PSP progressive supranuclear palsy, CBD corticobasal degeneration, VaP vascular parkinsonism, HpSp hippocampal sparing AD, FTLD-TDP frontotemporal lobar degeneration of a TDP-43 etiology, HpScl hippocampal sclerosis, GRN progranulin mutation, NBIA neurodegeneration with brain iron accumulation, 3R 3 repeat tau, 4R 4 repeat tau, M male, and F female