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Table 2 Subject characteristics of TDP-43, α-synuclein and off-target binding studies

From: An autoradiographic evaluation of AV-1451 Tau PET in dementia

Case Clinical diagnosis Neuropathologic diagnosis TDP type Tau isoform Braak Thal Age Sex Fig.
TDP-43
 6 svPPA AD (HpSp)/DLBD 0 3R + 4R VI 5 60 M  
 29 svPPA AD 0 3R + 4R VI 5 77 M Fig. 7 A-C
 30 agPPA FTLD-TDP/HpScl (GRN) A -- 0 0 64 M Fig. 7 D-F; Fig. 8 D-I
 31 FTD FTLD-TDP/HpScl (GRN) A -- 0 0 63 M Fig. 7G-I
 32 svPPA FTLD-TDP C -- 0 1 75 M Fig. 7 J-L
 33 agPPA FTLD-TDP C -- I 1 65 M  
 16 svPPA PiD 0 3R 0 0 74 M  
α-Synuclein
 34 DLB DLBD 0 -- 0 0 60 M  
 35 AD v DLB DLBD 0 -- II-III 1 76 M  
 36 MSA MSA (SND & OPCA) 0 -- 0 1 58 F  
Off-target
 1 Normal Normal 0 -- 0 0 81 F Fig. 9 A,B
 3 Normal Normal 0 -- 0 0 65 M Fig. 9 C,D
 19 PSP PSP 0 4R II-III 1 68 F Fig. 9 E,F
 6 svPPA AD (HpSp)/DLBD 0 3R + 4R VI 5 60 M Fig. 9 G,H
 36 MSA MSA (SND & OPCA) 0 -- 0 1 58 F Fig. 9 I,J
 30 agPPA FTLD-TDP/HpScl (GRN) A -- 0 0 64 M Fig. 9 K,L
 2 Normal Normal 0 -- 0 0 68 M Fig. 9 M-P
 31 FTD FTLD-TDP/HpScl (GRN) A -- 0 0 63 M Fig. 9 Q-T
 37 CBD NBIA 0 3R + 4R V 0 51 M  
 38 VaP Siderosis 0 -- 0 0 59 F  
  1. De-identified case numbers are referred to throughout the text and within Figs. TDP-43 type was performed using the recommended harmonized classification system [33]. Braak refers to neurofibrillary tangle stage [29] and Thal refers to amyloid phase [37]. Abbreviations: svPPA semantic variant of primary progressive aphasia, agPPA agrammatic variant of PPA, FTD frontotemporal dementia, DLB dementia with Lewy bodies, AD Alzheimer’s disease, MSA multiple systems atrophy, PSP progressive supranuclear palsy, CBD corticobasal degeneration, VaP vascular parkinsonism, HpSp hippocampal sparing AD, FTLD-TDP frontotemporal lobar degeneration of a TDP-43 etiology, HpScl hippocampal sclerosis, GRN progranulin mutation, NBIA neurodegeneration with brain iron accumulation, 3R 3 repeat tau, 4R 4 repeat tau, M male, and F female