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Table 1 Subject characteristics of tauopathies

From: An autoradiographic evaluation of AV-1451 Tau PET in dementia

Case

Clinical diagnosis

Neuropathologic diagnosis

TDP type

Tau isoform

Braak

Thal

Age

Sex

Fig.

Tau staging/maturity

 1

Normal

Normal

0

--

0

0

81

F

 

 2

Normal

Normal

0

--

0

0

68

M

Fig. 2 A-C; Fig. 8 A-C

 3

Normal

Normal

0

--

0

0

65

M

 

 4

Normal

PA

0

3R + 4R

III

3

94

F

 

 5

MCI

PA

0

3R + 4R

III

2

88

F

Fig. 2 D-F

 6

svPPA

AD (HpSp)/DLBD

0

3R + 4R

VI

5

60

M

Fig. 2 G-I

 7

AD

AD/DLBD

0

3R + 4R

VI

5

78

F

Fig. 3 A-D

 8

PSP

PART

0

3R + 4R

III-IV

0

57

F

 

 9

Normal

PART

0

3R + 4R

III-IV

0

89

F

 

 10

Normal

PART

0

3R + 4R

IV

0

82

F

Fig. 2 J-L

 11

MCI

Tangle predominant dementia

0

3R + 4R

III

0

81

F

 

 12

AD

Tangle predominant dementia

0

3R + 4R

IV

0

82

M

Fig. 2 M-O

 13

AD

Tangle predominant dementia/AGD

B

3R + 4R

III-IV

0

80

F

 

Tau isoforms

 6

svPPA

AD (HpSp)/DLBD

0

3R + 4R

VI

5

60

M

Fig. 4 A,B

 14

svPPA

PiD

0

3R

0

0

74

M

Fig. 4 C,D

 15

AD

PiD

0

3R

I

1

70

M

Fig. 4 E-H

 16

PiD

PiD

0

3R

0

0

72

M

Fig. 4 I-L

 17

agPPA

CBD/PA

0

4R

I-II

2

67

M

Fig. 5 A-D

 18

AD

CBD/AGD

0

4R

II

0

67

M

Fig. 5 E,F

 19

agPPA

PSP/AGD

0

4R

II

0

80

M

Fig. 5 G-J

 20

PSP

PSP

0

4R

II-III

1

68

F

Fig. 5 K,L

 21

PSP

PSP

0

4R

I

0

65

M

 

 22

MCI

AGD

0

4R

III

0

90

M

Fig. 5 M,N

 23

Normal

AGD

0

4R

III

1

91

M

Fig. 5 O,P

 24

PPND

FTDP-17 (MAPT N279K)

0

4R

0

0

49

M

Fig. 6 A-F

 25

PPND

FTDP-17 (MAPT N279K)

0

4R

0

0

50

F

Fig. 6 G,H

 26

FTD

FTDP-17 (MAPT P301L)

0

4R

0

0

53

M

Fig. 6 K-N

 27

FTD

FTDP-17 (MAPT P301L)

0

4R

I-II

0

52

M

Fig. 6 O,P

 28

FTD

FTDP-17 (MAPT R406W)

0

3R + 4R

5

0

66

F

Fig. 6 Q-T

 7

AD

AD/DLBD

0

3R + 4R

VI

5

78

F

 
  1. De-identified case numbers are referred to throughout the text and within Figs. TDP-43 type was performed using the recommended harmonized classification system [33]. Braak refers to neurofibrillary tangle stage [29] and Thal refers to amyloid phase [37]. Abbreviations: MCI mild cognitive impairment, svPPA semantic variant of primary progressive aphasia, AD Alzheimer’s disease, PSP progressive supranuclear palsy, PiD Pick’s disease, agPPA agrammatic variant of PPA, PPND pallido-ponto-nigral degeneration, FTD frontotemporal dementia, HpSp hippocampal sparing AD, DLBD diffuse Lewy body disease, AGD argyrophilic grains disease, CBD corticobasal degeneration, FTDP-17 frontotemporal dementia and parkinsonism linked to chromosome 17, 3R 3 repeat tau, 4R 4 repeat tau, F female, and M male