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Table 1 Subject characteristics of tauopathies

From: An autoradiographic evaluation of AV-1451 Tau PET in dementia

Case Clinical diagnosis Neuropathologic diagnosis TDP type Tau isoform Braak Thal Age Sex Fig.
Tau staging/maturity
 1 Normal Normal 0 -- 0 0 81 F  
 2 Normal Normal 0 -- 0 0 68 M Fig. 2 A-C; Fig. 8 A-C
 3 Normal Normal 0 -- 0 0 65 M  
 4 Normal PA 0 3R + 4R III 3 94 F  
 5 MCI PA 0 3R + 4R III 2 88 F Fig. 2 D-F
 6 svPPA AD (HpSp)/DLBD 0 3R + 4R VI 5 60 M Fig. 2 G-I
 7 AD AD/DLBD 0 3R + 4R VI 5 78 F Fig. 3 A-D
 8 PSP PART 0 3R + 4R III-IV 0 57 F  
 9 Normal PART 0 3R + 4R III-IV 0 89 F  
 10 Normal PART 0 3R + 4R IV 0 82 F Fig. 2 J-L
 11 MCI Tangle predominant dementia 0 3R + 4R III 0 81 F  
 12 AD Tangle predominant dementia 0 3R + 4R IV 0 82 M Fig. 2 M-O
 13 AD Tangle predominant dementia/AGD B 3R + 4R III-IV 0 80 F  
Tau isoforms
 6 svPPA AD (HpSp)/DLBD 0 3R + 4R VI 5 60 M Fig. 4 A,B
 14 svPPA PiD 0 3R 0 0 74 M Fig. 4 C,D
 15 AD PiD 0 3R I 1 70 M Fig. 4 E-H
 16 PiD PiD 0 3R 0 0 72 M Fig. 4 I-L
 17 agPPA CBD/PA 0 4R I-II 2 67 M Fig. 5 A-D
 18 AD CBD/AGD 0 4R II 0 67 M Fig. 5 E,F
 19 agPPA PSP/AGD 0 4R II 0 80 M Fig. 5 G-J
 20 PSP PSP 0 4R II-III 1 68 F Fig. 5 K,L
 21 PSP PSP 0 4R I 0 65 M  
 22 MCI AGD 0 4R III 0 90 M Fig. 5 M,N
 23 Normal AGD 0 4R III 1 91 M Fig. 5 O,P
 24 PPND FTDP-17 (MAPT N279K) 0 4R 0 0 49 M Fig. 6 A-F
 25 PPND FTDP-17 (MAPT N279K) 0 4R 0 0 50 F Fig. 6 G,H
 26 FTD FTDP-17 (MAPT P301L) 0 4R 0 0 53 M Fig. 6 K-N
 27 FTD FTDP-17 (MAPT P301L) 0 4R I-II 0 52 M Fig. 6 O,P
 28 FTD FTDP-17 (MAPT R406W) 0 3R + 4R 5 0 66 F Fig. 6 Q-T
 7 AD AD/DLBD 0 3R + 4R VI 5 78 F  
  1. De-identified case numbers are referred to throughout the text and within Figs. TDP-43 type was performed using the recommended harmonized classification system [33]. Braak refers to neurofibrillary tangle stage [29] and Thal refers to amyloid phase [37]. Abbreviations: MCI mild cognitive impairment, svPPA semantic variant of primary progressive aphasia, AD Alzheimer’s disease, PSP progressive supranuclear palsy, PiD Pick’s disease, agPPA agrammatic variant of PPA, PPND pallido-ponto-nigral degeneration, FTD frontotemporal dementia, HpSp hippocampal sparing AD, DLBD diffuse Lewy body disease, AGD argyrophilic grains disease, CBD corticobasal degeneration, FTDP-17 frontotemporal dementia and parkinsonism linked to chromosome 17, 3R 3 repeat tau, 4R 4 repeat tau, F female, and M male