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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: An autoradiographic evaluation of AV-1451 Tau PET in dementia

Fig. 6

Correlative autoradiography (ARG) and immunohistochemical (IHC) findings for assessment of MAPT mutation (N297K and P3012L) tau binding. a-f Case 24 - FTDP-17 (MAPT N279K), g, h Case 25 - FTDP-17 (MAPT N279K), k-n Case 26 - FTDP-17 (MAPT P301L), i, j, o, p Case 27 - FTDP-17 (MAPT P301L), q-t Case 28 - FTDP-17 (MAPT R406W). Shown from left to right AV-1451 ARG (AV-1451 blocking shown in the ARG insets) and PHF-1 IHC in the a, b, i, j frontal, c, d, k, l, q, r temporal, e, f midbrain, g, h, m-p amygdala, and s, t hippocampus. AV-1451 displaceable ARG signal is minimal but co-localizes in most cases with the most dense areas of PHF-1 immunopositivity (red arrows). Conversely, the MAPT R406W case shows moderate-strong binding in cortical structures with a laminar pattern similar to that observed in AD (green arrows). Scale bar for all full size brain sections at 5 mm, and for 20x zoomed insets at 25 μm. Arrowheads indicate 20x inset locations

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