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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: An autoradiographic evaluation of AV-1451 Tau PET in dementia

Fig. 5

Correlative autoradiography (ARG) and immunohistochemical (IHC) findings for assessment of 4R Tau (CBD, PSP, and AGD) binding. a-d Case 17 – CBD (rostral substantia nigra (rSN), substantia nigra (STN)), e, f Case 18 - CBD, g, h Case 19 - PSP, i-l Case 20 - PSP, m, n Case 22 - AGD, o, p Case 23 – AGD. Shown from left to right AV-1451 ARG (AV-1451 blocking shown in the ARG insets), and PHF-1 IHC in the a, b, e, f frontal and c, d subthalamic regions in CBD cases; g, h midbrain in PSP cases; i, j frontal, k, l subthalamic; and m-p hippocampal regions in AGD cases. AV-1451 displaceable ARG binding corresponding to PHF-1 is often minimal and when present corresponds (red arrows) with the most dense areas of PHF-1 immunopositivity but is overall weaker than in AD subjects. Strong, non-tau related, ARG displaceable signal in the substantia nigra (blue arrow) may be cross-reacting with neuromelanin containing nigral neurons. Minimal displaceable ARG signal in rSN corresponds to PHF-1 immunopositivity (g, k, red arrows). No AV-1451 signal is seen that corresponds to PHF-1 positive AGD (red dashed arrows, m-p). Scale bar for all full size brain sections at 5 mm, and for 20x zoomed insets at 25 μm. Arrowheads indicate 20x inset locations

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