Fig. 1

Examples of AV-1451 PET scans in subjects with various diseases. Correlative PET imaging (AD and Non-AD, Multimodality Imaging, rows 1-3) in an AD subject (1) with high AV-1451 signal (white regions), high PiB signal (white regions) and reduced FDG signal in an “AD” pattern (temporal, parietal and some frontal; colors indicate hypometabolism); an agPPA subject (2) with mild signal in the left temporal and frontal lobes on AV-1451 PET (orange arrows), normal PiB signal, and an “agPPA pattern” on FDG showing left sided dominant frontal and temporal hypometabolism and a svPPA subject (3) with very mild signal in the left temporal lobe on AV-1451 PET (orange arrows), normal PiB signal, and an svPPA pattern on FDG showing left sided dominant temporal hypometabolism. On row 4 (PSP and MAPT Mutation Carriers, AV-1451), from left to right, are AV-1451 PET images showing scattered, minimal signal in tauopathies secondary to PSP and MAPT mutations. The PSP subject showed signal in the brainstem that is likely nonspecific (red arrow). The left MAPT S305N mutation subject has severe (SV) symptoms and secondary ventricular enlargement and the next to the right has moderate (MOD) symptoms. The MAPT N279K mutation subject on the far right has relatively minimal (MIN) symptoms. Some very mildly increased AV-1451 signal is identified in the MAPT S305N subjects diffusely (green arrows) but it is clearly less intense than in the AD subject (1) but only mildly more than in the MAPT N279K subject (blue arrow). Yellow arrows show meningeal (PSP subject), basal ganglia (MAPT N279K subject), and choroid plexus signal (agPPA subject) and are likely non-specific binding regions