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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: ALS-linked misfolded SOD1 species have divergent impacts on mitochondria

Fig. 3

Four distinct mitochondrial subpopulations revealed by simultaneously immunolabeling with AMF7-63 and B8H10 misfolded SOD1-specific antibodies. a Flow cytometric analysis of isolated spinal cord mitochondria from symptomatic SOD1G93A animals labeled with AMF7-63 and B8H10. Analysis only includes events previously gated for MTG staining (MTG+). Percentage of misfolded SOD1+ events is shown for each subpopulation in a representative experiment. b Quantification of AMF7-63+B8H10 (green, circle), AMF7-63+B8H10+ (black, square) and B8H10+ AMF7-63 (blue, triangle) mitochondrial subpopulations from spinal cords of 14 week and early symptomatic SOD1G93A rats. Data are represented as percent of misfolded SOD1+ mitochondria (mean), n = 4–11 animals per subpopulation. ** P < 0.01

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